Provincial governor Shah Mahmood Miakhel said the explosives were planted in a number of Rickshaws which were detonated among civilians on Monday evening.
Miakhel further added that four civilians were killed and 8 others were wounded in the explosions.
According to Miakhel, the health condition of a number of wounded civilians has been reported as critical and there are fears that the death toll may further rise.
No individual or group including Taliban has so far claimed responsibility for the explosions.
Both Taliban and ISIS militants are active in some remote districts of Nangarhar province and the two groups are often attempting to carry out terrorist related activities in Jalalabad city and other parts of the province.