The provincial government media office in a statement said the operations to suppress the activities of the terror group under the name of Shaheen-18 concluded on Saturday.
The statement further added that the operations covered Achin district of Nangarhar where the loyalists of the terror group were actively operating.
The operations continued for 21 days, involving security personnel from all security institutions, including the Afghan Air Force.
According to the local officials, nearly 300 ISIS loyalists were killed or injured during the operations.
The operations by the Afghan forces were launched amid concerns that the loyalists of the terror group were looking to expand foothold and turn the region into a regional operational base.
The coalition officials estimated around 1,000 to 3,000 Islamic State fighters are stationed in eastern Afghanistan and are trying to establish a base of operations in the rugged mountains of Nangahar Province.