Hafiz Saeed Khan — a former Pakistani Taliban commander who hailed from Pakistan’s tribal region — was killed in the drone strike in Nangarhar district.
Khan was in January appointed the chief of the radical Iraq-and-Syria based outfit in Afghanistan and Pakistan, an area they call Khorasan.
“Daesh No 1 in Afghanistan, Hafiz Saeed, was killed in a drone strike in Nangarhar,” a source at National Directorate of Security (NDS) was quoted as saying.
This is not the first time Khan has been reported killed. The claim was not confirmed by independent sources or from the IS, also known as Daesh in Arabic.
He was the second top rebel killed in drone strikes in the past three days.
On Thursday, senior IS leader and former Pakistani Taliban spokesman Shahidullah Shahid was killed in a US drone attack in Afghanistan.
Shahid, also known as Sheikh Maqbool Orakzai, hailed from Pakistan’s Orakzai tribal region and was wanted in several cases of terrorism.
Khan and Shahid parted ways with Pakistani Taliban last year with five other rebels, and announced their allegiance to IS in October.
IS rebels are active in eastern provinces of Afghanistan, where they had a bloody clash with Taliban last month.