The incident took place earlier this afternoon in Surkh Rod district targeting a vehicle of the Afghan security forces.
The provincial public health officials confirmed that they have received nearly 50 dead or wounded bodies from the incident site so far.
The blast was carried out by a Rickshaw vehicle packed with explosives which was detonated near a mini bus belonging to the security forces.
A local security official confirmed that the bus was carrying personnel of the Afghan National Army and majority of the victims are army personnel.
No group including the Taliban militants have so far claimed responsibility behind the incident.
Nangarhar is among the relatively volatile provinces in eastern Afghanistan where anti-government armed militant groups are actively operating and frequently carry out insurgency activities.
Insurgents belonging to the Taliban group and the newly emerged Islamic State of Iraq and Syria (ISIS) terrorist group are actively operating in a number of its districts.